Hydrolysis of 3'-deoxy-3'-(thymin-1-yl)thymidine, 3'-deoxy-3'-(uracil-1-yl)
thymidine, and related furanoses with two nucleobases has been investigated
. 3'-beta-Substituted analogues, but not the 3'-alpha-substituted ones, aff
ord isomeric pyranose nucleosides as intermediates, which have been isolate
d (6c and 6d). Reduction of the hydrolysis products with sodium borohydride
afford the corresponding acyclic compounds (2'-deoxy-D-ribitol or D-ribito
l derivatives), which have been fully characterised as their peracetates. (
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