Synthesis of the enantiopure C15-C26 segment of phorboxazole A and B

Authors
Wolbers, P Misske, AM Hoffmann, HMR
Citation
P. Wolbers et al., Synthesis of the enantiopure C15-C26 segment of phorboxazole A and B, TETRAHEDR L, 40(24), 1999, pp. 4527-4530
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
24
Year of publication
1999
Pages
4527 - 4530
Database
ISI
SICI code
0040-4039(19990611)40:24<4527:SOTECS>2.0.ZU;2-R
Abstract
Two approaches towards an enantiopure C15-C26 segment of the phorboxazoles starting from the corresponding C20-C26 aldehyde are presented. A variety o f functionalized oxazoles have been synthesized via the rhodium(II) acetate catalyzed cycloaddition of dimethyl diazomalonate to substituted nitriles. (C) 1999 Elsevier Science Ltd. All rights reserved.