Pyridylmagnesium chlorides from bromo and dibromopyridines by bromine-magnesium exchange: A convenient access to functionalized pyridines

Authors
Trecourt, F Breton, G Bonnet, V Mongin, F Marsais, F Queguiner, G
Citation
F. Trecourt et al., Pyridylmagnesium chlorides from bromo and dibromopyridines by bromine-magnesium exchange: A convenient access to functionalized pyridines, TETRAHEDR L, 40(23), 1999, pp. 4339-4342
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
23
Year of publication
1999
Pages
4339 - 4342
Database
ISI
SICI code
0040-4039(19990604)40:23<4339:PCFBAD>2.0.ZU;2-H
Abstract
Various bromopyridines were converted to the corresponding pyridylmagnesium chlorides at room temperature by treatment with iPrMgCl. The resulting Gri gnard reagents were quenched by various electrophiles to afford functionali ze pyridines. The bromine-magnesium exchange of some dibromopyridines,vas a lso studied. (C) 1999 Elsevier Science Ltd. Alt rights reserved.