Annulation of functionalized hexadienones as an efficient regioselective approach to N-aryl-2-(trifluoromethyl)-4-pyridinamines

Authors
Cocco, MT Congiu, C Onnis, V
Citation
Mt. Cocco et al., Annulation of functionalized hexadienones as an efficient regioselective approach to N-aryl-2-(trifluoromethyl)-4-pyridinamines, TETRAHEDR L, 40(23), 1999, pp. 4407-4410
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
23
Year of publication
1999
Pages
4407 - 4410
Database
ISI
SICI code
0040-4039(19990604)40:23<4407:AOFHAA>2.0.ZU;2-Y
Abstract
Readily accessible fluorinated N-arylenaminones 3 were reacted with N,N-dim ethylformamide dimethylacetal to produce functionalized hexadienones 4. Rin g closure of 4 with ammonium acetate afforded selectively N-aryl-2-(trifluo romethyl)-4-pyridinamines 5 in good to excellent yields. (C) 1999 Elsevier Science Ltd. All rights reserved.