Chemoenzymatic synthesis of 2-substituted 2-fluoro-1,3-dioxygenated chiralbuilding blocks

Authors
Narisano, E Riva, R
Citation
E. Narisano et R. Riva, Chemoenzymatic synthesis of 2-substituted 2-fluoro-1,3-dioxygenated chiralbuilding blocks, TETRAHEDR-A, 10(7), 1999, pp. 1223-1242
Citations number
43
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
7
Year of publication
1999
Pages
1223 - 1242
Database
ISI
SICI code
0957-4166(19990409)10:7<1223:CSO22C>2.0.ZU;2-#
Abstract
A series of 2-substituted-2-fluoro-1,3-dioxygenated chiral building blocks are synthesized via a chemoenzymatic route using either (i) lipase catalyze d monohydrolysis of suitably functionalized malonic diesters, or (ii) lipas e catalyzed monoacetylation of suitably functionalized 1,3-propanediols. (C ) 1999 Elsevier Science Ltd. All rights reserved.