Enantioselective hydrogenation of beta-keto sulfones with chiral Ru(II)-catalysts: synthesis of enantiomerically pure butenolides and gamma-butyrolactones

Authors
Bertus, P Phansavath, P Ratovelomanana-Vidal, V Genet, JP Touati, AR Homri, T Hassine, BB
Citation
P. Bertus et al., Enantioselective hydrogenation of beta-keto sulfones with chiral Ru(II)-catalysts: synthesis of enantiomerically pure butenolides and gamma-butyrolactones, TETRAHEDR-A, 10(7), 1999, pp. 1369-1380
Citations number
46
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
7
Year of publication
1999
Pages
1369 - 1380
Database
ISI
SICI code
0957-4166(19990409)10:7<1369:EHOBSW>2.0.ZU;2-9
Abstract
A series of beta-hydroxy sulfones were synthesized with high enantioselecti vities via a new enantioselective ruthenium-catalyzed hydrogenation using M eO-BIPHEP as a ligand. Some beta-hydroxy sulfones were used in the synthesi s of optically active butenolides and gamma-butyrolactones with high yields and enantioselectivities over 95%. (C) 1999 Elsevier Science Ltd. All righ ts reserved.