Bh. Hoff et T. Anthonsen, Lipase-catalyzed resolution of eaters of 4-chloro-3-hydroxybutanoic acid: effects of the alkoxy group and solvent on the enantiomeric ratio, TETRAHEDR-A, 10(7), 1999, pp. 1401-1412
Various lipases have been investigated for their potential use as catalysts
for the resolution of esters of 4-chloro-3-hydroxybutanoic acid via transe
sterification in organic solvents. Rhizomucor miehei lipase was found to be
the most efficient lipase, with the enantiomeric ratio (E) being dependent
upon of the nature of the alkoxy group of the ester and the resolution med
ium. Higher E-values were obtained when transesterification was performed i
n benzene or carbon tetrachloride than was the case in hexane. In mixtures
of benzene and hexane the trend in E-values followed a linear relationship.
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