Haemodynamic measurements of the utero- and fetoplacental circulation during low-dose Aspirin treatment

A prospective randomized double-blind study of low-dose aspirin treatment ( 100 mg/d) was conducted on a population of 43 pregnant women at risk of pre gnancy-induced hypertension, preeclampsia, intrauterine growthretardation. Doppler ultrasound blood now measurements of the uterine arteries and the u mbilical cord, at the fetal and placental end, were obtained on a two-weekl y interval in between 18 to 40 weeks of gestation. During the course of pregnancy Doppler indices of both vessels decreased, w hereas the absolute velocity of the uterine arteries increased. Perfusion o f both vessels did not show any relevant differences in between the aspirin - and placebo-group. Both groups showed a similar median duration of gestat ion at time of delivery (278 d aspirin vs. 270 d placebo). Comparison of me dian birthweight (3152.5 g aspirin vs. 2900 g placebo) did not show any sig nificant difference. There were no haemodynamic effects of low-dose aspirin on the utero- and fetoplacental circulation to be demonstrated.