Report of the Chromosome 5 Workshop of the Sixth World Congress on Psychiatric Genetics

The Chromosome 5 Workshop heard new data on a schizophrenia susceptibility locus in the 5q23.3-q31.1 region. Sixty-two pedigrees from Finland gave a l od score of 1.36 at the CSF1R locus approximately 14 cM distal to IL9/D5S39 3, where positive results from three pedigree collections converged at the 1997 workshop, Though positive at CSF1R, the new data were only weakly posi tive at the IL9 (lod 0.46) and D5S393 (lod 0.07) loci themselves, The works hop also reviewed new evidence in the 5p14.1-p13.1 region, where a large pe digree of schizophrenia of Puerto Rican extraction has suggested a suscepti bility locus with a maximum lod score at D5S111, Twenty-one new pedigrees m ultiplex for schizophrenia in African Americans gave positive lod scores at D5S111 and flanking loci. In bipolar illness five genetically related pedi grees from the Saguenay-Lac-St, Jean region of Quebec identified a region o f interest at 5q31.3-q35.1, This region overlaps with the D5S423 locus and includes the D5S812 locus and the 5q34 region, all of which are consistent with linkage in at least one other study, Am, J, Med. Genet, (Neuropsychiat r, Genet,) 88: 229-232, 1999, (C) 1999 Wiley-Liss, Inc.