Chromosome Workshop: Chromosomes 11, 14, and 15

This report describes linkage data presented at the Workshop on Chromosomes 11, 14, and 15 at the Sixth World Congress of Psychiatric Genetics in Bonn , Germany, together with relevant linkage data submitted to the chair and c o-chair, and it is presented in the context of the previous literature conc erning these chromosomes. We have attempted to collate current linkage data to provide a guide to potentially interesting findings on chromosomes 11, 14, and 15 for the phenotypes of bipolar disorder, schizophrenia, alcoholis m, autism, and spelling and reading disability. We discuss methodological l imitations and provide chromosome ideograms and tables summarizing findings to date. The most promising region currently appears to be 15q13-q15 in th e region of the alpha 7 nicotinic receptor for the phenotype of schizophren ia land, perhaps, more generally for functional psychosis). Additionally, 1 5q11-q13 in the region of GABRB3 holds interest, as a potential site of a s usceptibility gene for autism. Two regions on chromosome 11, 11p15 in the r egion of tyrosine hydroxylase gene and 11q22-q23 in the region of DRD2, con tinue to retain some interest for functional psychosis. Am. J, Med. Genet. (Neuropsychiatr. Genet,) 88:244-254, 1999. (C) 1999 Wiley-Liss, Inc.