Characterization of biological features and chemosensitivity of a new experimental lung metastasis model originating from the MXT mouse mammary adenocarcinoma
S. Farinelle et al., Characterization of biological features and chemosensitivity of a new experimental lung metastasis model originating from the MXT mouse mammary adenocarcinoma, ANTICANC R, 19(2A), 1999, pp. 1171-1180
The present study shows how an original mouse metastatic lung model was est
ablished from the MXT mammary adenocarcinoma, This metastatic model was obt
ained by injecting the C/MET clone into the tail veins of B6D2F1 mice. The
C/MET clone corresponds to one of eleven cell clones that were isolated in
vitro from the MXT model. Of these 11 clones, only the C/MET leans to lung
metastatic tumor development when injected i.v. into mice. Furthermore, the
C/MET clone colonizes the lung only. The present data show that the C/MET
metastatic model and the MXT parental line are weakly (if reference is made
to the P388 leukemia model) sensitive to adriamycin, clyclophosphamide and
etoposide. However; under specific experimental conditions, the chemosensi
tivity of the C/MET model can be significantly increased. The C/MET model t
herefore appears to be an interesting pharmacological tool to test new inve
stigational agents with anti-tumor potentialities to lung metastases.