Activity of gatifloxacin compared to those of five other quinolones versusaerobic and anaerobic isolates from skin and soft tissue samples of human and animal bite wound infections

The activity of gatifloxacin against 308 aerobes and 112 anaerobes isolated from bite wound infections was studied. Gatifloxacin was active at less th an or equal to 0.016 mu g/ml against all 148 Pasteurella isolates (eight sp ecies and three subspecies) tested and all other aerobes tested, including Actinobacillus-Haemophilus spp., Eikenella corrodens, Neisseria weaveri, We eksella zoohelcum, staphylococci, and streptococci. Fusobacteria were somet imes resistant. Gatifloxacin MICs at which 90% of the isolates were inhibit ed were 0.125 mu g/ml against Bacteroides tectum and Prevotella spp., 0.25 mu g/ml against Porphyromonas spp., and 0.5 mu g/ml against peptostreptococ ci.