P. Ringwald et al., In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum, ANTIM AG CH, 43(6), 1999, pp. 1525-1527
The in vitro activities of pyronaridine, alone and in combination with esta
blished antimalarial drugs, were assessed by isotopic microtest. Pyronaridi
ne was highly active against all Cameroonian isolates. ii positive correlat
ion was observed bet between the response to pyronaridine and that to chlor
oquine. Drug combination studies shelved synergy between pyronaridine and p
rimaquine, additive effects with 4-aminoquinolines, and weak antagonism wit
h dihydroartemisinin, antifolates, or amino alcohols.