In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum

Authors
Ringwald, P Eboumbou, ECM Bickii, J Basco, LK
Citation
P. Ringwald et al., In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum, ANTIM AG CH, 43(6), 1999, pp. 1525-1527
Citations number
19
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
6
Year of publication
1999
Pages
1525 - 1527
Database
ISI
SICI code
0066-4804(199906)43:6<1525:IVAOPA>2.0.ZU;2-H
Abstract
The in vitro activities of pyronaridine, alone and in combination with esta blished antimalarial drugs, were assessed by isotopic microtest. Pyronaridi ne was highly active against all Cameroonian isolates. ii positive correlat ion was observed bet between the response to pyronaridine and that to chlor oquine. Drug combination studies shelved synergy between pyronaridine and p rimaquine, additive effects with 4-aminoquinolines, and weak antagonism wit h dihydroartemisinin, antifolates, or amino alcohols.