Interstrain variation in the human cytomegalovirus DNA polymerase sequenceand its effect on genotypic diagnosis of antiviral drug resistance

Authors
Chou, SW Lurain, NS Weinberg, A Cai, GY Sharma, PL Crumpacker, CS
Citation
Sw. Chou et al., Interstrain variation in the human cytomegalovirus DNA polymerase sequenceand its effect on genotypic diagnosis of antiviral drug resistance, ANTIM AG CH, 43(6), 1999, pp. 1500-1502
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
6
Year of publication
1999
Pages
1500 - 1502
Database
ISI
SICI code
0066-4804(199906)43:6<1500:IVITHC>2.0.ZU;2-7
Abstract
The polymerase (pol) coding sequence was determined for 40 independent clin ical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Seque nce alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons, Almost all variation occurred outside of cons erved functional domains where resistance mutations have been identified.