Pharmacokinetics and pharmacodynamics of amoxicillin-sulbactam, a novel aminopenicillin-beta-lactamase inhibitor combination, against Escherichia coli

Authors
Bantar, C Nicola, F Arenoso, HJ Galas, M Soria, L Dana, D Rossi, A Bianchini, H Jasovich, A
Citation
C. Bantar et al., Pharmacokinetics and pharmacodynamics of amoxicillin-sulbactam, a novel aminopenicillin-beta-lactamase inhibitor combination, against Escherichia coli, ANTIM AG CH, 43(6), 1999, pp. 1503-1504
Citations number
10
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
6
Year of publication
1999
Pages
1503 - 1504
Database
ISI
SICI code
0066-4804(199906)43:6<1503:PAPOAA>2.0.ZU;2-7
Abstract
We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a nov el drug combination, and its pharmacodynamics against Escherichia coli in 1 2 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericid al and urine inhibitory activities in most volunteers were observed against E. coli strains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 stra ins) and high (greater than or equal to 16-mg/liter) (47 strains), respecti vely.