Three different types of atrial septal defect in three members of a family.

Most of the time atrial septal defects (ASD) are sporadic. Familial forms a re caracterised by the same type of the ASD, and are frequently associated by other cardiac, osteoarticular (Holt-Oram syndrome) or atrioventricular c onductions abnormalities (ostium secundum ASD with prolonged PR, sinus veno sus ASD with sinusal bradyarrhythmia). This report describes a family in which the father and his two children pre sent an ASD, each one of a different type (ostium primum ASD, ostium secund um ASD, sinus venosus ASD), without any other associated malformations. To the best of our knowledge, this is the first report of a family in which th ree different ASD types are present.