R. Hromas et al., Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension, BIOC BIOP R, 258(3), 1999, pp. 737-740
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Chemokines are a family of related proteins that regulate leukocyte infiltr
ation into inflamed tissue and play important roles in many disease process
es. Chemokines are divided into two major groups, CC or CXC, based on their
sequence around the amino terminal cysteines, We report here, the isolatio
n of a novel murine CC chemokine termed ALP for its amino terminal peptide
sequence. This novel chemokine is distantly related to other CC chemokines
(37% identity with murine Exodus-1/LARC/Mip-3 alpha), but has a unique carb
oxy terminal extension. It is expressed preferentially in testis, heart, an
d liver, which is atypical for CC chemokines, (C) 1999 Academic Press.