Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives

Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial pep tide derived from bovine LF, inhibited thiobarbituric acid-reactive substan ce (TBARS) formation in a iron / ascorbate-induced liposomal phospholipid p eroxidation system. The inhibition of TBARS formation occurred with N-acyla ted 9-mer peptides with a core sequence of LFcin B and, compared to LFcin B , their antioxidant effect was clearly observed at a concentration almost 1 00 times lower.