Citation
Mgm. Santos et al., A screening for the antiviral effect of extracts from Brazilian marine algae against acyclovir resistant herpes simplex virus type 1, BOTAN MARIN, 42(3), 1999, pp. 227-230
Citations number
15
Categorie Soggetti
Aquatic Sciences
Journal title
BOTANICA MARINA
ISSN journal
00068055
→ ACNP
Volume
42
Issue
3
Year of publication
1999
Pages
227 - 230
Database
ISI
SICI code
0006-8055(199905)42:3<227:ASFTAE>2.0.ZU;2-E
Abstract
In order to verify the antiviral activity of extracts from Brazilian marine
algae, aqueous cold extracts of eight species belonging to the classes Pha
eophyceae, Rhodophyceae and Chlorophyceae were assayed for antiherpes simpl
ex virus (HSV-1) activity using an acyclovir-resistant strain. All extracts
inhibited the propagation of HSV-1 in HEp-2 cells at non-toxic concentrati
ons with Laminaria abyssalis the most potent species. These results suggest
the Brazilian algae are promising sources of natural antiviral agents for
the treatment of acyclovir resistant HSV-1 infections.