Aims-To report the appearances of iridocorneal endothelial (ICE) syndrome f
rom real time, white light confocal microscopy.
Methods-Three consecutive patients, each with ICE syndrome, were examined p
rospectively. Corneal specular and confocal microscopic examinations were p
erformed in all three patients. In the first patient, a penetrating keratop
lasty was performed and the cornea was examined by light and scanning elect
ron microscopy. No surgery was performed in the remaining two patients.
Results-In the first patient corneal oedema prevented endothelial specular
microscopy. Confocal microscopy performed before penetrating keratoplasty s
uccessfully revealed abnormal epithelial-like endothelial cells. Histologic
al examinations of the cornea following penetrating keratoplasty revealed t
he presence of multilayered endothelial cells with epithelial features (mic
rovilli). In the remaining two patients, specular microscopy showed the pre
sence of ICE cells with typical dark/light reversal. Confocal microscopy de
monstrated groups of endothelial cells with epitheloid appearances. In all
three patients, the contralateral endothelial appearance was normal by spec
ular and confocal microscopy, except for moderate endothelial polymegathism
in one patient. Epithelial-like endothelial cells were characterised by pr
ominent nuclei on confocal microscopy.
Conclusions-The application of confocal microscopy indicates that the ICE s
yndrome is characterised by epitheloid changes in the endothelium. Confocal
microscopy may be used to diagnose the ICE syndrome by demonstrating epith
elial-like endothelial cells with hyperreflective nuclei. This technique is
especially of value in cases of corneal oedema, since specular microscopy
may fail to image the endothelium in such cases.