Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue

Authors
Citation
Hj. Freeman, Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue, CAN J GASTR, 13(4), 1999, pp. 347-350
Citations number
28
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
CANADIAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
08357900 → ACNP
Volume
13
Issue
4
Year of publication
1999
Pages
347 - 350
Database
ISI
SICI code
0835-7900(199905)13:4<347:HAAALC>2.0.ZU;2-Y
Abstract
A 66-year old woman was seen repeatedly over a decade to remove recurrent c olonic adenomas and investigate episodes of watery diarrhea. Although the d iarrhea was believed to be due to lymphocytic colitis, she developed weight loss, hypoproteinemia and hyposplenism that resulted in further stud ies, specifically to exclude celiac disease. Small intestinal biopsies, however, showed severely 'flattened' villous architecture with trichrome-positive s ubepithelial collagenous deposits, characteristic of collagenous sprue. Ant iendomysial antibodies, known serological markers of celiac disease, were a lso detected. While collagenous sprue has been considered a distinct small intestinal disorder, the constellation of clinical and pathological finding s in this patient suggests a close link with adult celiac disease.