Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice

Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Signifi cant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were obse rved. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 leve l only) was observed. Pulmonary and hepatic ODC activities were reduced (19 -59%) by DMA treatment. Overall, these biochemical studies show that mice a re much less responsive to DMA than rats. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.