This is a review of the electrophysiologic changes occurring at different t
imes following myocardial infarction, both in the infarcted region (substra
te) and in areas remote from the infarct. Regulators of channel function wh
ich might contribute to re-modeling, including autocrine/paracrine factors
involved in ion channel gene regulation, are discussed. (C) 1999 Elsevier S
cience B.V. All rights reserved.