Cytonemes: Cellular processes that project to the principal signaling center in Drosophila imaginal discs

Citation
Fa. Ramirez-weber et Tb. Kornberg, Cytonemes: Cellular processes that project to the principal signaling center in Drosophila imaginal discs, CELL, 97(5), 1999, pp. 599-607
Citations number
41
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
00928674 → ACNP
Volume
97
Issue
5
Year of publication
1999
Pages
599 - 607
Database
ISI
SICI code
0092-8674(19990528)97:5<599:CCPTPT>2.0.ZU;2-J
Abstract
Wing imaginal disc cells in Drosophila develop by using information receive d from a signaling center associated with the anterior/posterior compartmen t border. We show here that disc cells have thin, actin-based extensions (c ytonemes) that project to this signaling center. Cytonemes can be induced w hen cells from the lateral flanks of a wing disc are cultured next to cells from the A/P border or next to a source of fibroblast growth factor. Mouse limb bud cells also grow projections during a brief culture period, indica ting that cytonemes are an attribute of both vertebrate and invertebrate ce lls. We suggest that cytonemes may be responsible for some forms of long-ra nge cell-cell communication.