Unusually prolonged survival and childhood-onset epilepsy in a case of alobar holoprosencephaly

Alobar holoprosencephaly is one of the most severe congenital malformations of the central nervous system. Most affected infants are stillborn or have a very short life-span. The survivors can present with neonatal seizures a nd/or infantile spasms. We report on an unusually long-lived patient with a lobar holoprosencephaly and minor facial dysmorphism, who developed general ized epilepsy during childhood.