Serum soluble transferrin receptor in the diagnosis of iron deficiency in chronic liver disease

Fifty-one consecutive patients with chronic liver disease (CLD) underwent i nvestigations of their iron status (full blood count, serum iron [Fe], tota l iron binding capacity [TIBC], transferrin saturation [TS], serum ferritin and serum soluble transferrin receptor [sTfR] level). Twenty-six patients were anaemic; 12 patients had iron deficiency, and 10 had iron deficiency a naemia (IDA). The median (range) sTfR in the IDA patients was 16.6 (11.2-24 .8) mg/l, compared with 6.6 mg/l (11.2-24.8) in the 16 patients with anaemi a due to other causes (P = 0.01), The sensitivity of sTfR for diagnosing ir on deficiency in CLD was 91.6% (100% if only anaemic patients are included) and the specificity was 84.6%. Patients with haemolysis and recent blood l oss may have falsely elevated sTfR levels. The results suggest that the sTf R is as useful as serum ferritin in identifying a potentially treatable cau se of anaemia in CLD.