Solution-phase chemical library synthesis using polymer-assisted purification techniques

During the past few years, polymer-assisted solution-phase synthesis has be come a prevalent method for the parallel synthesis of chemical libraries. T his methodology allows for intermediate and final product purification by v arious resin-based sequestration techniques, which allow for the removal of excess reactants, by-products or side products from solution-phase reactio ns. The methodology has continued to expand, providing the practitioner wit h a broad range of ingenious purification methods, allowing single-step tra nsformations as well as multistep syntheses to be performed in solution. Th e polymer-assisted solution-phase technology is currently being utilized fo r both the synthesis of lead generation and lead optimization libraries in the pharmaceutical arena and has also expanded into other disciplines.