Mass spectrometric analysis in combinatorial chemistry

The continuing success of the combinatorial approach is heavily reliant on analytical methodologies, which allow for the rapid and accurate characteri sation of medicinally relevant molecules from compound libraries. Mass spec trometry has recently been touted as the most suitable tool for a range of combinatorial applications such as structural elucidation and screening. Th e refinement of conventional methods, developments of techniques such as Fo urier transform ion cyclotron resonance and new screening methodologies hav e allowed the medicinal chemist to tackle the growing analytical challenges posed by combinatorial chemistry.