Diversity assessment

Several themes have been highlighted recently in both conferences and publi cations: the availability of product-focused and pharmacophore-based method s for the analysis and design of combinatorial libraries; the power of cell -based methods for molecular similarity, diversity and library design appli cations; methods for 'rational' diverse subset selection (with applicabilit y to library design); the need for specialized optimization programs for th e design of combinatorial libraries that maximize the use of common reagent s; and the concept of 'drug-likeness' and its importance in the design of c ombinatorial libraries.