Comparative tablet and rheological properties of new microcrystalline cellulose: Direct compression and wet granulation methods

Authors
Opota, D Prinderre, P Kaloustian, J Joachim, G Piccerelle, P Ebba, F Reynier, JP Joachim, J
Citation
D. Opota et al., Comparative tablet and rheological properties of new microcrystalline cellulose: Direct compression and wet granulation methods, DRUG DEV IN, 25(6), 1999, pp. 795-799
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
25
Issue
6
Year of publication
1999
Pages
795 - 799
Database
ISI
SICI code
0363-9045(1999)25:6<795:CTARPO>2.0.ZU;2-Y
Abstract
The overall objective of this study was to compare the rheological properti es and tablet characteristics of two new varieties of celluloses (Vivacel 1 01 and 102), recently produced and commercialized, with the classical varie ties of celluloses (Avicel and Elcema). The results showed no significant d ifferences in the rheological properties of Vivacel and Avicel, while signi ficant differences were found between the two celluloses and Elcema. Furthe rmore, there were no statistically significant differences in the disintegr ation times and T-d values of Vivacel and Avicel. In conclusion, it was fou nd that these new celluloses offer all the known advantages of Avicel.