Ultrasmall enzyme electrodes with response time less than 100 milliseconds

Glucose sensors with submicrometer tip diameter have been constructed by us e of platinum-deposited flame etched carbon fiber electrodes. These electro des have been coated with glucose oxidase and result in response times as L ow as 85 ms. Moreover. there is a linear relationship between sensor tip di ameter and response time. Although the response is, at present, only stable over a limited number of flow injection analysis runs, it appears that sen sors with tip diameter less than 100 nm might provide response times of a f ew milliseconds if enzyme kinetics do not become rate limiting.