Effects of a low-calorie diet on resting metabolic rate and serum tri-iodothyronine levels in obese children

The purpose of the study was to examine the effects of weight loss on resti ng metabolic rate (RMR) and on serum T3 levels in obese children and to inv estigate whether RMR changes are related to T3 changes. Sixty-four healthy, overweight, children (age: 12.1 +/- 1.1 years, body mass index 29.3 +/- 4. 3 kg/m(2)) were studied during a 6-week weight reduction programme. RMR (by indirect calorimetry) total T3, total T4, TSH and fat-free mass (FFM) (by anthropometry) were measured at baseline and after 6 weeks of dietary treat ment. Weight loss resulted in a 10.1% decline in RMR (P < 0.01) and a 23.4% decrease in serum T3 levels (P < 0.001). RMR was correlated with FFM befor e (r = 0.78, P < 0.001) and after weight loss (r = 0.76, P < 0.001). The ch anges in RMR were positively correlated with the changes in FFM (r = 0.48, P < 0.05) but also with the changes in serum T3 levels(r = 0.47, P < 0.05). The initial T3 levels predicted the subsequent fall in T3 that occurred af ter 6 weeks of dietary treatment (r = -0.60, P < 0.001). Conclusions A significant decrease in serum T3 concentrations and resting m etabolic rate occurred as a result of a 6-week weight reduction programme i n an obese child population. The decline in T3 levels combined with fat-fre e mass loss could be responsible for the reduction in resting metabolic rat e.