Thermodynamic influences on the fidelity of iron-sulphur cluster formationin proteins

Authors
Armstrong, FA Williams, RJP
Citation
Fa. Armstrong et Rjp. Williams, Thermodynamic influences on the fidelity of iron-sulphur cluster formationin proteins, FEBS LETTER, 451(2), 1999, pp. 91-94
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
451
Issue
2
Year of publication
1999
Pages
91 - 94
Database
ISI
SICI code
0014-5793(19990521)451:2<91:TIOTFO>2.0.ZU;2-L
Abstract
In an organism, two thermodynamic factors are important in ensuring that ho mometallic [4Fe-4S] cubane clusters are formed in preference to clusters co ntaining heterometals such as Zn or Cu. These are the electronic resonance stabilisation, which boosts the binding of Fe(II) within an Fe-S cluster re lative to its normally low position in the Irving-Williams order, and atten uation of the cytoplasmic concentrations of competing metals such as Zn or Cu by specific ligands. (C) 1999 Federation of European Biochemical Societi es.