Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise

The aim of the present study was to investigate the concentration of ubiqui none-10 (Q10), at rest,in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementat ion. Another aim was to explore whether adenine nucleotide catabolism, lipi d peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or a Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. Then was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in eith er group. Plasma hypoxanthine and uric acid concentrations increased marked ly after each exercise test session in both groups. After the training peri od, the postexercise increase in plasma hypoxanthine was markedly reduced i n both groups, but the response was partially reversed after the recovery p eriod. It was concluded that Q10 supplementation increases the concentratio n of Q10 in plasma but not in skeletal muscle.