Gas chromatographic analysis of fosfomycin in plasma for pharmacokinetic analysis

An efficient method for gas chromatographic analysis of fosfomycin in plasm a was developed for preliminary investigations of the bioavailability in po ultry of 3 commercial complexes of fosfomycin: a levorotatory Ca(-) salt, a racemic Ca(+/-) salt, and a tromethamine (THAM) salt, The method was used to determine whether the less expensive racemic mixture would provide equiv alent levels of fosfomycin in blood as the pure Ca(-) form and the THAM sal t, The THAM salt, a more expensive product to market, was thought to have t he greatest bioavailability. The assay is selective, sensitive, and applica ble to pharmacokinetic analysis.