One-dimensional diffusion of proteins along DNA - Its biological and chemical significance revealed by single-molecule measurements

Evidence for sliding of proteins along DNA has been provided by many kineti c studies, but single-molecule-based measurements have uncovered distinct p roblems, the solutions of which may lead us to an understanding of new mech anisms for gene regulation. Furthermore, they reveal a deep problem lying b etween chemistry and physics regarding the seemingly simple binding between DNA and protein. Single-molecule dynamics provides a tool to solve this pr oblem without prejudgments or unsound assumptions.