Plasticity of feedback inputs in the apteronotid electrosensory system

Weakly electric fish generate an electric field surrounding their body by m eans of an electric organ typically located within the trunk and tail, Elec troreceptors scattered over the surface of the body encode the amplitude an d timing of the electric organ discharge (EOD), and central components of t he electrosensory system analyze the information provided by the electrorec eptor afferents, The electrosensory system is used for electrolocation, for the detection and analysis of objects near the fish which distort the EOD and for electrocommunication. Since the electric organ is typically located in the tail, any movement of this structure relative to the rest of the bo dy alters the EOD field, resulting in large changes in receptor afferent ac tivity. The amplitude of these reafferent stimuli can exceed the amplitudes of near-threshold electrolocation signals by several orders of magnitude. This review summarizes recent studies of the South American weakly electric fish Apteronotus leptorhynchus aimed at determining how the animals differ entiate self-generated or reafferent electrosensory stimuli from those that are more behaviorally relevant. Cells within the earliest stages of centra l electrosensory processing utilize an adaptive filtering technique which a llows the system preferentially to attenuate reafferent as well as other pr edictable patterns of sensory input without degrading responses to more nov el stimuli. Synaptic plasticity within the system underlies the adaptive co mponent of the filter and enables the system to learn to reject new stimulu s patterns if these become predictable, A Ca2+-mediated form of postsynapti c depression contributes to this synaptic plasticity. The filter mechanism seen in A. leptorhynchus is surprisingly similar to adaptive filters descri bed previously in mormyrid weakly electric fish and in elasmobranchs, sugge sting that this mechanism may be a common feature of sensory processing sys tems.