Correlation of functional and structural measurements in eyes suspected ofhaving glaucoma

Purpose: This study was conducted to determine the correlation between stru ctural changes in the retinal nerve fiber layer (RNFL) and functional loss detected on short-wavelength automated perimetry (SWAP) in a population of patients with suspected glaucoma. Methods: With a selection criteria of intraocular pressure (IOP) more than 21 mmHg and normal results of conventional automated perimetry, 49 eyes of 49 patients with ocular hypertension were enrolled in the study. The SWAP w as performed with a modified Humphrey field analyzer, and visual field inde xes (mean deviation [MD], corrected pattern standard deviation [CPSD]) were calculated. Semiquantitative RNFL scores were given separately to diffuse and localized defects of the RNFL. Results: The MD increased significantly with higher diffuse and total RNFL scores, with good correlation coefficients. A weak correlation was found be tween CPSD and diffuse, total, and localized RNFL scores. Conclusion: Diffuse RNFL loss are associated with abnormalities in visual f ield indexes (MD), whereas focal structural damage showed no correlation wi th visual field loss.