Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

Citation
P. Richmond et al., Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory, J INFEC DIS, 179(6), 1999, pp. 1569-1572
Citations number
17
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
179
Issue
6
Year of publication
1999
Pages
1569 - 1572
Database
ISI
SICI code
0022-1899(199906)179:6<1569:MSCCVI>2.0.ZU;2-2
Abstract
The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody p ersistence and response to boosting with 10 ag Of meningococcal C polysacch aride were assessed. The meningococcal conjugate vaccine produced fewer loc al reactions than concurrent routine immunizations. Total serogroup C-speci fic immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericida l antibody (SBA) geometric mean titers (GMTs) rose from <1:4 to 1:1057 at 5 months and fell by 14 months to 1:19. Following boosting, anti-C-specific immunoglobulin GMC rose to 15.9 mu g/mL and SEA GMT to 1:495, Antibody resp onses in the 10-mu g dose cohort were significantly higher at 5 months (P < .01) than in the 2-mu g dose cohort but were lower after polysaccharide bo osting (P = .02), This meningococcal conjugate vaccine was well tolerated a nd immunogenic and induced immunologic memory in infants.