Antifungal metabolites from the marine sponge Pachastrissa sp.: New bengamide and bengazole derivatives

This paper reports the studies of components of an undescribed sponge in th e genus Pachastrissa sp., collected along the Djibouti coast. The extract s howed activity against Candida albicans. Six new bengazoles (1-6) and a new bengamide, named bengamide L (16), in addition to the known bengazoles (7- 11), bengamides A (12), B (13), E (14), and F (15), and a lactone (17) are described in this paper. All structures were determined on the basis of spe ctroscopic studies.