A new bistetrahydrofuran acetogenin, salzmanin (1), was isolated from the M
eOH extract of Annona salzmanii, in addition to the known compounds, squamo
cin, almunequin, bullatalicin, and annonacin. The structure of 1 was elucid
ated by spectroscopic methods, including LSIMS-MS technique, and confirmed
by a chemical transformation. The cytotoxic activity of 1 and squamocin was
investigated.