Novel multicomponent organogels containing an aqueous phase are described,
and some properties which influence their potential as delivery devices for
hydrophilic drugs and vaccines are discussed. The gel is produced by prepa
ring a hot water-in-oil (w/o) emulsion using sorbitan monostearate, a nonio
nic surfactant which is also the organogelator, as the principal emulsifyin
g agent. On cooling at room temperature, the w/o emulsion sets to an opaque
, semisolid, thermoreversible organic gel. Cooling the emulsion results in
a reduced solubility of the sorbitan monostearate in the oil, with a corres
ponding decrease in solvent-surfactant affinities, causing surfactant self-
assembly into aggregates. The microstructure of the w/o gel is seen by ligh
t microscopy to consist of a network of tubules and fibrils (containing the
aqueous phase) dispersed in the organic medium. X-ray diffraction and free
ze-fracture studies suggest that the tubular aggregates in the w/o gel are
made up of surfactant molecules arranged in inverted bilayers and that the
aqueous phase is accommodated within these inverted bilayers, bound by the
polar headgroups of the surfactant molecules. The presence of water in the
tubular skeleton of the organic gels results in the establishment of percol
ating electroconductive aqueous channels in the organogel. Increasing the w
ater content of a w/o gel causes the surfactant tubules to swell with a cor
responding increase in conductivity until the tubules are saturated. Furthe
r increase in the water content results in the excess water accumulating in
droplets within the organic medium and a decrease in conductivity as the g
el integrity is compromised. The w/o gels (containing a model antigen, radi
olabeled bovine serum albumin, in the aqueous phase) have demonstrated depo
t properties after intramuscular administration to mice, entrapped antigen
being released over a period of days.