Z. Li et al., Protective effects of pseudoginsenoside-F-11 on scopolamine-induced memoryimpairment in mice and rats, J PHARM PHA, 51(4), 1999, pp. 435-440
This study assessed the effects of pseudoginsenoside-F-11, a component of P
anax quinque-folium L., on scopolamine-impaired memory performance in mice
and rats.
In the one-trial step-down and step-through passive avoidance tests, althou
gh pseudoginsenoside-F-11 used alone did not affect passive avoidance behav
iour in naive mice, the latency of avoidance shortened by intraperitoneal s
copolamine (2 mg kg(-1)) was prolonged after intragastric administration of
pseudoginsenoside-F-11 (2 or 4 mg kg(-1), for five days) in both test syst
ems in mice. In the water-maze test, in mice, the time taken to locate the
platform after administration of pseudoginsenoside-F-11 was shorter than th
at after administration of scopolamine (1 mg kg(-1), i.p.). In the two-way
active avoidance response test, the latency of avoidance was significantly
shorter for the pseudoginsenoside-F-11- (1 2 or 2.4 mg kg(-1), i.g. for fiv
e days) and scopolamine-treated group than for the group of rats given scop
olamine only (2 mg kg(-1), i.p.). The percentage avoidance was also reduced
after intraperitoneal injection of scopolamine, but was reversed by admini
stration of pseudoginsenoside-F-11.
These results suggest that pseudoginsenoside-F-11 antagonized the memory dy
sfunction induced by scopolamine. However, the mechanism of the memory faci
litative action of pseudoginsenoside-F-11 merits further elucidation.