The effects of level of expression of a jellyfish Shaker potassium channel: a positive potassium feedback mechanism

Citation
Ng. Grigoriev et al., The effects of level of expression of a jellyfish Shaker potassium channel: a positive potassium feedback mechanism, J PHYSL LON, 517(1), 1999, pp. 25-33
Citations number
17
Categorie Soggetti
Physiology
Journal title
JOURNAL OF PHYSIOLOGY-LONDON
ISSN journal
00223751 → ACNP
Volume
517
Issue
1
Year of publication
1999
Pages
25 - 33
Database
ISI
SICI code
0022-3751(19990515)517:1<25:TEOLOE>2.0.ZU;2-L
Abstract
1. When jellyfish Shaker potassium channels (jShak2) are heterologously exp ressed in Xenopus oocytes at different levels they demonstrate density-depe ndent changes in electrical and kinetic properties of macroscopic currents. 2. The activation and inactivation properties of jShak2 channels depend on the extracellular potassium concentration. In this study we present experim ental data which show that expression-dependent changes in kinetic and elec trical properties of jShak2 macroscopic currents can be explained by the po sitive feedback effect of dynamic accumulation of K+ in the perimembranal s pace.