Systemic lupus erythematosus and Castleman's disease

Lymphadenopathy is a common finding in systemic lupus erythematosus (SLE), yet lymphoid malignancy is rare. Typically, adenopathy associated with SLE responds to glucocorticoid therapy. We evaluated a patient with a diagnosis of SLE who had progressive lymphadenopathy despite receiving aggressive co rticosteroid therapy for SLE associated thrombocytopenia. Histopathology in itially revealed an aggressive plasmacytosis characteristic of Castleman's disease (CD), CD, or angiofollicular hyperplasia, is a rare lymphoprolifera tive neoplasm that has features overlapping many autoimmune diseases. This disorder should be considered in autoimmune diseases with unremitting or pr ogressive adenopathy.