Vascular compliance as a measure of biological age

OBJECTIVES: To determine the measure of vascular compliance most closely re lated to age. DESIGN: A review of 22 studies relating aortic compliance to age and a discussion of other factors related to vascular compliance. MEASUREMENTS: Aortic compliance, elastic modulus, postmortem aortic changes , pulse wave velocity in the aorta, common carotid, lower limb and upper li mb. RESULTS: 1. Aortic compliance and carotid artery compliance is closely rela ted to age; 2. Compliance in the peripheral arteries, in 16 reports, appear s less closely related to age; 3. There is evidence that aortic compliance is related to hypertension, cardiac function, and left ventricular hypertro phy and can be increased by exercise, hormonal therapy, antioxidant and ant ihypertensive treatment; and 4. Vascular compliance is more closely related to chronological age than other measures such as skin inelasticity, greyin g of hair, baldness etc. CONCLUSIONS: Because of the close relationship between aortic and carotid c ompliance and chronological age, deviation from the age-predicted norm (bio logical age) may prove to be a good predictor of cardiovascular pathology.