Synthesis of the potent analgesic compound (+/-)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

Authors
Habermann, J Ley, SV Scott, JS
Citation
J. Habermann et al., Synthesis of the potent analgesic compound (+/-)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents, J CHEM S P1, (10), 1999, pp. 1253-1255
Citations number
38
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
10
Year of publication
1999
Pages
1253 - 1255
Database
ISI
SICI code
0300-922X(19990521):10<1253:SOTPAC>2.0.ZU;2-Z
Abstract
A ten-step synthesis of (+/-)-epibatidine 1 is described, using an organise d array of polymer supported reagents and sequestering agents in a successi ve manner. No chromatographic purification steps are required to afford the product in >90% purity.