Muscle quality and age: Cross-sectional and longitudinal comparisons

Citation
Ej. Metter et al., Muscle quality and age: Cross-sectional and longitudinal comparisons, J GERONT A, 54(5), 1999, pp. B207-B218
Citations number
49
Categorie Soggetti
Public Health & Health Care Science","Medical Research General Topics
Journal title
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN journal
10795006 → ACNP
Volume
54
Issue
5
Year of publication
1999
Pages
B207 - B218
Database
ISI
SICI code
1079-5006(199905)54:5<B207:MQAACA>2.0.ZU;2-V
Abstract
We addressed whether muscle quality (force per unit muscle mass) changes wi th age in cross-sectional and longitudinal analyses from three groups from the Baltimore Longitudinal Study of Aging: (1) Isometric arm strength studi ed cross-sectionally in 617 subjects with muscle mass estimated by cross-se ctional area (CSA)from arm circumference and by 24-hour urinary creatinine excretion (CREAT) (2) longitudinal study for 10 to 25 years in 412 men usin g the same measures as the first group; and (3) isometric knee extensor str ength studied cross-sectionally in 675 subjects; muscle mass estimated by G REAT CSA from thigh circumference, and leg nonosseous fat free mass (FFM)fr om dual energy x-ray absorptiometry. Muscle quality declined in both arm an d leg with age in cross-sectional analyses using GSA and FFM, but not GREAT No age-associated arm muscle quality declines were observed longitudinally using GREAT or GSA. The relationship between muscle quality and age is dep endent on how muscle mass is estimated and on whether subjects are studied cross-sectionally or longitudinally. In addition, GREAT may measure a muscl e property not accounted for by CSA or FFM.