Spontaneously hypertensive rats: Expression of the erythrocyte membrane proteins in second generation hybrids F-2 (SHR x WKY)

'The aim of the study was to determine characteristics of phenotype (blood pressure level, heart rate) of second generation hybrids of SHR and WKY rat s (F-2) and to investigate its relationship with contents of some proteins in erythrocyte membrane. There were significant differences between SHR and WKY rats in quantitative content of a series of membrane protein fractions . flood pressure level correlated with expression of alpha- and beta-spectr in, some proteins from bands 4.1a, 4.2, 4.5, and tropomyosin. Directions of correlations for some protein fractions were sex related and correlation c oefficients for male and female animals had opposite signs. These data demo nstrated existence of disturbed regulation of expression of the plasmatic c ell membrane proteins in spontaneously hypertensive rats.