Synthesis of heterotelechelic poly(ethylene glycol)s and their characterization by MALDI-TOF-MS

Authors
Volcker, NH Klee, D Hanna, M Hocker, H Bou, JJ de Ilarduya, AM Munoz-Guerra, S
Citation
Nh. Volcker et al., Synthesis of heterotelechelic poly(ethylene glycol)s and their characterization by MALDI-TOF-MS, MACRO CH P, 200(6), 1999, pp. 1363-1373
Citations number
33
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR CHEMISTRY AND PHYSICS
ISSN journal
10221352 → ACNP
Volume
200
Issue
6
Year of publication
1999
Pages
1363 - 1373
Database
ISI
SICI code
1022-1352(199906)200:6<1363:SOHPGA>2.0.ZU;2-S
Abstract
Two heterotelechelic poly(ethylene glycol)s were synthezised by end group m odification of alpha-hydro-omega-hydroxy-poly(oxyethylene) (PEG). The first reaction route starts from heterobifunctional alpha-hydro-omega-octadecano yloxy-poly(oxyethylene) (400) and comprises the synthesis of alpha-hydro-om ega-carboxymethoxy-poly(oxyethylene). The second pathway starts from homote lechelic PEG(400) and leads to alpha-(2-propenyl)-omega-carboxymethylthio-p oly(oxyethylene). Purification of the desired products was accomplished by means of ion exchange chromatography on DEAE Sephadex. PEG derivatives were characterized by means of NMR, IR, HPLC and GPC. MALDI-TOF-MS recorded in the reflectron mode served as a fine method that provides information on ch emical composition as well as molecular weight.